abstract：RATIONALE:The development of chronic obstructive pulmonary disease (COPD) in smokers and their susceptibility to infections is not fully understood. Recent evidences suggest that Clara cells play a part in host defense, immunomodulatory response and airways remodelling through the production of specific factors such as...

journal_title：Respiratory medicine

authors： Braido F,Riccio AM,Guerra L,Gamalero C,Zolezzi A,Tarantini F,De Giovanni B,Folli C,Descalzi D,Canonica GW

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Combination therapy should be prescribed to patients with moderate to severe asthma after daily long-term treatment with inhaled inhaled corticosteroids (ICS) has been tried without obtaining adequate control and it is not indicated to be used as first line treatment in asthma. OBJECTIVES:To describe the us...

journal_title：Respiratory medicine

authors： Breton MC,Lelorier J,Forget A,Blais L

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Natriuretic peptides are considered as reliable indicators of left-heart failure (HF) and are useful for differential diagnosis of dyspnoea. AIM:We evaluated the clinical significance of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with chronic hypercapnic respiratory failure (CHRF). ME...

journal_title：Respiratory medicine

authors： Budweiser S,Luchner A,Jörres RA,Heinemann F,Hitzl AP,Schmidbauer K,Riegger G,Pfeifer M

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Poor mask fit and mouth leak are associated with nasal symptoms and poor sleep quality in patients receiving domiciliary non-invasive ventilation (NIV) through a nasal mask. Normal subjects receiving continuous positive airways pressure demonstrate increased nasal resistance following periods of mouth leak. ...

journal_title：Respiratory medicine

authors： Tuggey JM,Delmastro M,Elliott MW

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Sarcoidosis is characterised by a T-lymphocytic alveolitis with a typically increased T4/T8 ratio. The diagnostic value of this ratio is under debate. AIM OF THE WORK:We prospectively evaluated the influence of BAL pre-lavage and the impact of bronchial contamination on BAL differential cell count in 108 BA...

journal_title：Respiratory medicine

authors： Reichenberger F,Kleiber B,Baschiera B,Bubendorf L,Brutsche M,Dalquen P,Tamm M

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Alpha-1-antitrypsin deficiency (AATD) is significantly underdiagnosed. The early detection of AATD would enable affected persons to make lifestyle changes such as quitting smoking. It was the aim of the study to determine whether the combination of an awareness program with the offer of a cost-free diagnosti...

journal_title：Respiratory medicine

authors： Bals R,Koczulla R,Kotke V,Andress J,Blackert K,Vogelmeier C

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To compare the effects of once-daily ciclesonide and twice-daily fluticasone propionate in patients with moderate persistent asthma. METHODS:Patients aged 12-75 years with moderate bronchial asthma entered a 1-4 week run-in period. For inclusion into the 12-week, randomized, open-label treatment period, pati...

journal_title：Respiratory medicine

authors： Boulet LP,Bateman ED,Voves R,Müller T,Wolf S,Engelstätter R

更新日期：2007-08-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) affects 6% of the general population and is the fourth-leading cause of death in the United States with severe and very severe disease accounting for 15% and 3% of physician diagnoses of COPD. Guidelines make few recommendations regarding providing the provision of care for...

journal_title：Respiratory medicine

authors： Ambrosino N,Simonds A

更新日期：2007-08-01 00:00:00

abstract：:Beclometasone dipropionate (BDP) extrafine is a hydrofluoroalkane-based, chlorofluorocarbon (CFC)-free inhalation aerosol. This study was conducted to determine whether BDP extrafine and CFC-fluticasone proprionate (FP) aerosols were equivalent in terms of efficacy and tolerability in children with symptomatic mild-to...

journal_title：Respiratory medicine

authors： van Aalderen WM,Price D,De Baets FM,Price J

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The role of computerised tomography (CT) lung density measurements in objective quantification of emphysema is uncertain. The aim of this study was to determine normal reference values for CT lung density measurements and investigate their utility in identifying subjects with clinical emphysema. METHODS:Nor...

journal_title：Respiratory medicine

authors： Marsh S,Aldington S,Williams MV,Nowitz MR,Kingzett-Taylor A,Weatherall M,Shirtcliffe PM,McNaughton AA,Pritchard A,Beasley R

更新日期：2007-07-01 00:00:00

abstract：QUESTION OF THE STUDY:We studied whether prophylactic use of noninvasive pressure support ventilation (NIPSV) administered pre- and postoperatively may reduce the postoperative pulmonary function impairment. PATIENTS AND METHODS:Prospective randomized clinical trial. Thirty-nine patients with a preoperative FEV(1) <70...

journal_title：Respiratory medicine

authors： Perrin C,Jullien V,Vénissac N,Berthier F,Padovani B,Guillot F,Coussement A,Mouroux J

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Bronchiectasis is a common disabling but rarely fatal disease. However the long-term prognosis and risk factors for mortality are not well known. OBJECTIVE:The aim of this study was to determine prospectively the survival and predictive factors of mortality in patients with bronchiectasis, during 4-year fol...

journal_title：Respiratory medicine

authors： Onen ZP,Gulbay BE,Sen E,Yildiz OA,Saryal S,Acican T,Karabiyikoglu G

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Diagnosing asthma cannot be always easy. It is important to consider the validity of the diagnostic tests, and/or how much more commonly they are positive in patients with asthma compared to healthy subjects and, particularly, to patients with asthma-like symptoms. OBJECTIVE:To evaluate the validity of diag...

journal_title：Respiratory medicine

authors： Di Lorenzo G,Mansueto P,Esposito-Pellitteri M,Ditta V,Castello F,Lo Bianco C,Leto-Barone MS,Di Fede G,Traverso M,Rotolo G,Vigneri S,Rini G

更新日期：2007-07-01 00:00:00

abstract：:We aimed to study trends in gender-related differences in incidence, and prevalence for long-term oxygen therapy due to chronic obstructive pulmonary disease. Another aim was to study survival after onset of oxygen therapy. Prospectively followed were 5689 Swedish patients, who were prescribed oxygen therapy because o...

journal_title：Respiratory medicine

authors： Franklin KA,Gustafson T,Ranstam J,Ström K

更新日期：2007-07-01 00:00:00

abstract：:Exposure to air pollution is associated with adverse health effects, with particulate matter (PM) and ozone (O(3)) both indicated to be of considerable importance. Diesel engine exhaust (DE) and O(3) generate substantial inflammatory effects in the airways. However, as yet it has not been determined whether a subseque...

journal_title：Respiratory medicine

authors： Bosson J,Pourazar J,Forsberg B,Adelroth E,Sandström T,Blomberg A

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVES:Acid gastro-esophageal reflux has been shown associated with chronic pulmonary diseases. The role of non-acid refluxes in these children is still unknown. Therefore we investigated the prevalence of acid and non-acid refluxes, and their association with desaturations, in children with chronic pulmonary sympt...

journal_title：Respiratory medicine

authors： Thilmany C,Beck-Ripp J,Griese M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Posturally induced changes in minute ventilation in patients may be autonomically driven. This study aimed to test whether changes in autonomic tone with posture differed between normal and asthmatic subjects and whether this related to changes in indices of ventilation. METHODS:Ten patients with type 1 bri...

journal_title：Respiratory medicine

authors： Mukhopadhyay J,Bates R,Manney S,Ayres JG

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) are responsible for a high utilisation of the health care resources, and the cost is expected to increase. Physiological measures of lung function often fail to describe the impact the symptoms have on exacerbations, days of hospitalisation, and on a...

journal_title：Respiratory medicine

authors： Emtner MI,Arnardottir HR,Hallin R,Lindberg E,Janson C

更新日期：2007-05-01 00:00:00

abstract：:Vocal cord dysfunction (VCD) is characterised by paradoxical vocal cord adduction during inspiration or throughout the respiratory cycle, it results in wheeze, stridor, cough and dyspnoea. Although asthma and VCD can coexist, patients with VCD are frequently misdiagnosed with refractory asthma. It can severely restric...

journal_title：Respiratory medicine

authors： Goldstein R,Bright J,Jones SM,Niven RM

更新日期：2007-04-01 00:00:00

abstract：:Samples of lung tissue, taken at time of lung transplant, from 13 Dutch Caucasian patients with idiopathic pulmonary arterial hypertension (iPAH) and 14 patients with non-idiopathic PAH were studied for the presence of human herpes virus-8 (HHV-8). By immunohistochemical staining, in none of patients expression of HHV...

journal_title：Respiratory medicine

authors： Bresser P,Cornelissen MI,van der Bij W,van Noesel CJ,Timens W

更新日期：2007-04-01 00:00:00

abstract：:In this review, we aim to lead the readers through the historical highlights of pathophysiological concepts and treatment of asthma. Understanding the nature and links of asthma has modeled our diagnostic, pathophysiological and therapeutic thinking and acting. The recognition of its heterogeneous nature in combinatio...

journal_title：Respiratory medicine

authors： Diamant Z,Boot JD,Virchow JC

更新日期：2007-03-01 00:00:00

abstract：AIM:To examine tobacco use among teenagers, identify factors related to tobacco use, as well as evaluate the outcome of a smoking prevention program. METHODS:From age 7/8 to 14/15, annual questionnaires about asthma and allergy have been completed in the OLIN paediatric study in Northern Sweden. From 12/13 years, ques...

journal_title：Respiratory medicine

authors： Hedman L,Bjerg A,Perzanowski M,Sundberg S,Rönmark E

更新日期：2007-03-01 00:00:00

abstract：INTRODUCTION:The release of tumor necrosis factor (TNF-alpha) is increased in sarcoidosis patients. TNF-alpha exerts its effect by binding to specific cell surface receptors. There are only fragmentary data concerning the expression of tumor necrosis factor receptors (TNFRs) on bronchoalveolar lavage fluid (BALF) and p...

journal_title：Respiratory medicine

authors： Kieszko R,Krawczyk P,Chocholska S,Bojarska-Junak A,Jankowska O,Król A,Roliński J,Milanowski J

更新日期：2007-03-01 00:00:00

abstract：:There is an increasing body of evidence suggesting that altered vascular permeability may be an important component of the pathogenesis of acute mountain sickness (AMS). Vascular endothelial growth factor (VEGF) is a potent permeability factor subject to hypoxic regulation but its role in the pathogenesis of AMS is ye...

journal_title：Respiratory medicine

authors： Dorward DA,Thompson AA,Baillie JK,MacDougall M,Hirani N

更新日期：2007-03-01 00:00:00

abstract：:Subcutaneous emphysema is a common condition occurring after chest injury. It may also be observed in association with pneumothorax or pneumomediastinum as a result of pathological changes in the respiratory tract. Spontaneous subcutaneous emphysema in absence of pneumothorax or pneumomediastinum is rare. We report a ...

journal_title：Respiratory medicine

authors： Pandey D,Jaret P,Sharma R,Sharma A,Thakur S

更新日期：2007-02-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic seronegative spondyloarthritis with the major histocompatibility antigen HLA B27. Pulmonary involvement in AS is rare and is usually in the form of upper lobe fibrocavitary disease. Herein, we present a case with recurrent pleural and pericardial effusion without apical fibrobu...

journal_title：Respiratory medicine

authors： Erkan L,Uzun O,Findik S,Atici AG,Ozkaya S

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Selection of heath-related quality of life (HRQL) instruments that are most responsive to changes in HRQL prevents investigators from drawing false-negative conclusions about the effectiveness of an intervention. The objective of this study was to compare the responsiveness of the Chronic Respiratory Questio...

journal_title：Respiratory medicine

authors： Puhan MA,Guyatt GH,Goldstein R,Mador J,McKim D,Stahl E,Griffith L,Schünemann HJ

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Although rabbits are becoming popular as pets, data about the characteristics of allergic sensitization to rabbit allergens in patients without professional exposure are scarce. AIMS OF THE STUDY:To determine the characteristics of allergic sensitization to pet rabbits, and the role of direct and indirect e...

journal_title：Respiratory medicine

authors： Liccardi G,Piccolo A,Dente B,Salzillo A,Noschese P,Gilder JA,Russo M,D'Amato G

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Bronchial stenosis (BS) is currently found in 7-15% of lung transplantation (LT) recipients. Current treatment strategies have included Nd:Yag laser, cryotherapy, bougie dilatation and stent placement. Bronchoscopic balloon dilatation has been used as alternative treatment in a few cases with controversial r...

journal_title：Respiratory medicine

authors： De Gracia J,Culebras M,Alvarez A,Catalán E,De la Rosa D,Maestre J,Canela M,Román A

更新日期：2007-01-01 00:00:00

abstract：:Antigen detection is a useful adjunct for the diagnosis of histoplasmosis. The purpose of this study was to evaluate antigen detection in bronchoalveolar lavage (BAL) fluid using an improved second-generation Histoplasma antigen assay. Antigen was detected in 16 of 19 (84%) cases of histoplasmosis and 5 of 6 (83.3%) b...

journal_title：Respiratory medicine

authors： Hage CA,Davis TE,Egan L,Parker M,Fuller D,Lemonte AM,Durkin M,Connelly P,Joseph Wheat L,Blue-Hnidy D,Knox KS

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:IL-4 receptor alpha chain is crucial for the binding and signaling of IL-4, which mediates isotype switching and IgE production. The gene of IL-4 receptor alpha chain is a candidate gene for asthma and atopy. OBJECTIVES:To determine whether Ile50Val and Q576R polymorphisms of IL-4 receptor alpha chain gene ...

journal_title：Respiratory medicine

authors： Zhang W,Zhang X,Qiu D,Sandford A,Tan WC

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:There is little information available on the features of initial presentation of bronchiectasis and documentation of the onset and progress of symptoms leading up to this. Therefore a study was performed on a large cohort of adult patients presenting to Monash Medical Centre (MMC) to survey the course of the...

journal_title：Respiratory medicine

authors： King PT,Holdsworth SR,Freezer NJ,Villanueva E,Holmes PW

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:The efficacy and safety of 750-mg, 5-day levofloxacin was recently shown to be comparable to 500-mg, 10-day levofloxacin in a randomized, double-blind, multicentre clinical trial for mild-to-severe community-acquired pneumonia (CAP). This subgroup analysis attempted to compare the safety and efficacy of a sh...

journal_title：Respiratory medicine

authors： Shorr AF,Khashab MM,Xiang JX,Tennenberg AM,Kahn JB

更新日期：2006-12-01 00:00:00

abstract：:The aim of the study was to investigate possible mechanisms of epithelial injury in normal subjects exposed to environmentally relevant concentrations of ozone. Fifteen healthy non-smoking subjects (M:F 12:3) were studied. Five of the 15 subjects were exposed to filtered air, six were exposed to ozone 100 parts per bi...

journal_title：Respiratory medicine

authors： Morrison D,Rahman I,MacNee W

更新日期：2006-12-01 00:00:00

abstract：:Diffuse panbronchiolitis (DPB) is a distinctive form of small airway disease, which is characterized by chronic inflammation with lymphocyte infiltration around bronchioles. The aim of this study was to evaluate the importance of factors related to apoptosis in peribronchiolar lymphocytes of DPB. We employed immunohis...

journal_title：Respiratory medicine

authors： Kadota J,Mizunoe S,Mukae H,Mito K,Kishi K,Tokimatsu I,Nagai H,Tomono K,Kohno S,Nasu M

更新日期：2006-11-01 00:00:00

abstract：AIM:To assess the effect of intrapleural urokinase, vis-à-vis simple pleural drainage, on residual pleural thickening in a series of patients suffering from loculated tuberculous pleural effusion. PATIENTS AND METHOD:Twenty-nine patients (21 males and 8 females) with loculated pleural effusion were studied. These pati...

journal_title：Respiratory medicine

authors： Cases Viedma E,Lorenzo Dus MJ,González-Molina A,Sanchis Aldás JL

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Bronchiectasis (BQs) is an uncommon disease with the potential to cause devastating complications. All patients with BQs have cough and chronic sputum production that may have a great impact on patient's quality of life. Upper airway symptoms are also frequent in patients with BQs. Associations between upper...

journal_title：Respiratory medicine

authors： Guilemany JM,Alobid I,Angrill J,Ballesteros F,Bernal-Sprekelsen M,Picado C,Mullol J

更新日期：2006-11-01 00:00:00

abstract：RATIONALE:Infradiagnosis of chronic obstructive pulmonary disease (COPD) may be related to the lack of knowledge about the disease and/or the scarce use of diagnostic procedures. This study analyses the frequency of respiratory symptoms and the knowledge about COPD in the general population, together with the use of sp...

journal_title：Respiratory medicine

authors： Miravitlles M,de la Roza C,Morera J,Montemayor T,Gobartt E,Martín A,Alvarez-Sala JL

更新日期：2006-11-01 00:00:00

abstract：STUDY OBJECTIVES:Surgical lung biopsy (SLB) plays an important role in the diagnosis of interstitial pneumonia, however, the occurrence of acute respiratory failure following SLB remains largely unreported. We evaluated the incidence, clinical features, therapy and prognosis of acute exacerbation of interstitial pneumo...

journal_title：Respiratory medicine

authors： Kondoh Y,Taniguchi H,Kitaichi M,Yokoi T,Johkoh T,Oishi T,Kimura T,Nishiyama O,Kato K,du Bois RM

更新日期：2006-10-01 00:00:00

abstract：INTRODUCTION:The 6-min walk test (6MWT) has prognostic value in various pulmonary disorders including idiopathic pulmonary fibrosis (IPF). We determined the individual prognostic accuracy of distance walked and oxygen saturation during the 6MWT in patients with IPF. We defined a new composite index, the distance-satura...

journal_title：Respiratory medicine

authors： Lettieri CJ,Nathan SD,Browning RF,Barnett SD,Ahmad S,Shorr AF

更新日期：2006-10-01 00:00:00